| Pair Name | Chlorogenic acid, Regorafenib | ||
| Phytochemical Name | Chlorogenic acid (PubChem CID: 1794427 ) | ||
| Anticancer drug Name | Regorafenib (PubChem CID: 11167602 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Chlorogenic acid, Regorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Expression | CASP7 | hsa840 | |
| In Vitro Model | PLC/PRF/5 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0485 |
| Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 | |
| Result | This drug combination could be considered as a safe and more effective approach in HCC therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells. Int J Mol Sci. 2018 May 19;19(5):1518. doi: 10.3390/ijms19051518. | Click |
